Control of thalamocortical activity by HCN channel modulation
The control of thalamocortical firing plays a key role in a variety of brain functions including determination of vigilance states, cognition and consolidation of memory. HCN channels expressed in the thalamocortical system have been supposed to play a crucial role in this process since they integrate electrical with neurotransmitter inputs linked to the cAMP system. In this proposal we will thoroughly examine this hypothesis by analyzing novel genetic mouse models expressing HCN channels with impaired responsiveness to cAMP. To this end we will combine cellular, network and whole animal approaches.