CRC 870

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Fast and precise inhibitory connections in the mammalian sound localization system: the role of axon morphology and myelination patterns for action potential conduction

What are the mechanisms regulating the timing of inputs in microcircuits? One central, yet often neglected parameter is myelination, which shapes the conduction velocity of action potentials along the axon. In the previous funding period, we have discovered pronounced differences in axonal myelination between functionally distinct regions of an otherwise homogenous neural structure. Here, we will quantify how these morphological specialisations impact spike conduction velocity, synaptic transmission and the functional processing in vivo. Moreover, we will determine the role of experience on myelination in the context of temporal fine-tuning of microcircuits.