Excitability of leaky coincidence detector neurons in the auditory brainstem
MSO neurons encode interaural time differences (ITDs) with a resolution of tens of microseconds. This tremendous ITD sensitivity relies on features of the synaptic inputs and these neurons' fast membrane time constants resulting from two voltage-gated ion channels that are already open at rest. Under in vivo conditions, continuous synaptic bombardment further decreases the input resistance and thus, it is puzzling how MSO neurons can be excited supra-threshold. We will investigate the synaptic, somatic and axonal contribution to the excitability of MSO neurons under in vivo like conditions using in vitro (patch clamp, voltage imaging) and in silico (biophysical modeling) techniques.