CRC 870

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Functional recovery of pretectal visuo-motor relay neurons after injury in zebrafish

Principal Investigators:

Adult anamniote vertebrates have a large capacity to regenerate central nervous tissue, including the generation of new neurons, and thus offer the possibility to study general aspects of restorative neurogenesis. This project aims at establishing in adult zebrafish an experimental model for testing the hypothesis that lesion-induced neurogenesis of an identified set of pretectal neurons and reinsertion into the defined sensory-motor circuitry for optokinetic reflexes causes a spatio-temporally adequate recovery of visuo-motor responses. The novelty is the combinatorial approach that uses concepts and techniques of stem cell research and functional analyses of the network responsible for a quantifiable motor behavior.