CRC 870

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Connectivity and function of regenerated neurons in the cerebral cortex

Principal Investigators:

The connectivity of neurons is essential for brain function, yet virtually nothing is known how regenerated neurons integrate into an existing neuronal network in the adult brain. Here we use different ways to regenerate neurons in a model of layer-specific neuron ablation in the cerebral cortex to then examine their functional integration. This is done by the monosynaptic rabies virus tracing technique that we adapted to this project in previous funding period and by live imaging the responses to visual stimuli upon integration of new neurons into the visual cortex.