Mechanisms of dynamic polarization of newly-born interneurons
As neurons are born, they transform from progenitors to cells with well-defined geometry – how the underlying polarization emerges, especially in interneurons in vivo, is not well understood. Here, we will take advantage of the optical and genetic accessibility of the zebrafish retina to reveal the cellular, subcellular and molecular mechanisms of interneuron polarization. We will focus on two cell-types of highly divergent morphology that emerge from the same mitotic division, bipolar cells and (unipolar) amacrine cells. Our study will elucidate how the shape that defines interneurons is developmentally established, and which steps would need to be recapitulated during cell replacement.