CRC 870

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Mechanisms of target selection during post-injury remodelling of neuronal circuits

Functional recovery following spinal cord injury critically depends on axonal detour circuit formation. During circuit formation, new corticospinal collaterals initiate and maintain contacts with appropriate interneurons. Regulation occurs at two levels: First, certain interneurons are never contacted indicating that molecular cues allow identification of suitable targets. Second, once contacts are established, some are maintained while others are removed indicating that functional properties of the interneurons determine contact stabilization. In this project we want to understand 1) which molecular cues initiate/prevent contact formation on spinal targets and 2) how the functional properties of the target neurons lead to maintenance/removal of contacts.