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A04

Behavioral state dependent processing of chemosensory cues in higher brain centers

Principal Investigators:

Adjusting reactions to sensory cues in a state-dependent manner is essential for any animal. The neural underpinnings of this adjustment are poorly understood. Using Drosophila, we recently showed that innate olfactory behavior is processed via parallel pathways depending on context. Surprisingly, feeding-state dependent processing of innate odor cues relies on the fly’s learning and memory center, the mushroom body (MB). In the next funding period, we will map the MB circuit in detail including input, output, and neuromodulatory neurons in order to understand how brains integrate olfactory information with internal state.