A14
Regulation of myelinated axon structure by communication between axons and oligodendrocytes
Principal Investigators:
We are interested in understanding how myelinated axons form and remodel to control nervous system function. The role of axonal myelination has been underestimated for a long time in being a passive and static structure that electrically insulates axons. However, it has become clear over the past years myelination can be (i) highly specific to fine tune conduction, and (ii) dynamically change in response to neuronal activity. In this project here, we aim to elucidate the mechanisms that govern formation, maintenance, and remodelling of axon myelination patterns using in vivo imaging and genetic manipulation of axonal structure and physiology using zebrafish as model organism.