Control of neuronal circuit activity by HCN channel modulation
HCN channels (HCN1-4) are molecular coincidence detectors that integrate extra- and intracellular input signals to a discrete cellular output. In this project, we examine to which extent the regulation of HCN4 by the cAMP system shapes the firing properties of thalamocortical neurons. In particular, we are interested in the question of how this modulation controls brain functions and behavior. In connection to these experiments, the specific impact of HCN channels present in GABAergic thalamic interneurons is studied. Finally, the role of cGMP-dependent regulation of HCN1 for hippocampal synaptic transmission and spatial memory formation is investigated.