The influence of neuronal activity on oligodendrocyte proliferation and differentiation in the adult brain
Oligodendrocyte progenitor cells (OPCs) in the adult brain continue to generate myelinating oligodendrocytes throughout life. OPCs, that are constantly proliferating, are closely associated with synapses and nodes of Ranvier and their proliferation and differentiation properties can be changed by voluntary physical exercise. These findings prompt the analysis of modulators of neuronal activity and their influence on OPCs´ proliferation and differentiation and their finely tuned balance. Here we want to study by different means how the activity dependent regulation of OPC proliferation and differentiation contributes to an experience dependent modification of neuronal circuits function.