Prof. Dr. Mark Hübener - Ludwig-Maximilians-Universität München
LMU  |  TUM  |  MPI |  Helmholtz Zentrum |  BCCN Munich |  MCN-GSN |  GRK 1091 |  GRK 1373 |  DFG

Prof. Dr. Mark Hübener

Principal Investigator

Overall aim of the project is the characterization of the cellular mechanisms of plasticity in mouse visual cortex using chronic, in vivo two photon imaging of neuronal structure and function. We will induce retinal lesions and follow ensuing changes in receptive field organization of neurons expressing genetically encoded calcium indicators. We will also study the sprouting of GFP labeled intracortical axons, thought to underlie the functional changes observed after retinal lesions. The structural remodeling of thalamic input fibers to the visual cortex will be imaged after monocular deprivation and recovery from deprivation.
Max-Planck-Institute of Neurobiology
Department of Cellular and Systems Neurobiology
Research Group Visual System Development
Am Klopferspitz 18A
82152 Planegg-Martinsried

Phone: 089-8578-3697
Fax: 089-8995-0036

Email: Email
Website: Prof. Dr. Mark Hübener
  • Hübener M, Bonhoeffer T (2010)
Searching for engrams. [Abstract]
Neuron. 2010 Aug 12;67(3):363-71. Review
  • Hofer SB, Mrsic-Flogel TD, Bonhoeffer T, Hübener M (2009)
Experience leaves a lasting structural trace in cortical circuits. [Abstract]
Nature. 2009 Jan 15;457(7227):313-7. Epub 2008 Nov 12
  • Holtmaat A, Bonhoeffer T, Chow DK, Chuckowree J, De Paola V, Hofer SB, Hübener M, Keck T, Knott G, Lee WC, Mostany R, Mrsic-Flogel TD, Nedivi E, Portera-Cailliau C, Svoboda K, Trachtenberg JT, Wilbrecht L (2009)
Long-term, high-resolution imaging in the mouse neocortex through a chronic cranial window. [Abstract]

Nat Protoc. 2009;4(8):1128-44